Does Zoloft Cause Weight Gain?

weight gain from zoloft

A lot of people are worried that taking Zoloft, a common antidepressant, might cause them to gain weight. The chance of this happening really varies from person to person, but overall, research shows that about 11% of individuals who take antidepressants, including Zoloft, experience a weight gain of at least 5% in their first year of treatment.

The Relationship Between Zoloft and Weight Gain

There is not complete clarity on the connection between Zoloft and weight gain, but professionals theorize that Zoloft and other antidepressants could potentially cause weight gain by affecting the brain’s neurotransmitters serotonin and histamine, which control appetite. Additionally, some individuals may feel tired or lethargic while taking Zoloft, leading to a decrease in physical activity and, in turn, weight gain.

Duration of Zoloft UseWeight Gain in lbs per year
6 months1.2 to 2.4 lbs
1 year1.5 to 2.6 lbs

Extent of Weight Gain

To clarify, Zoloft users have been found to experience a weight increase of 1% to 1.6% of their original body weight over a span of 6 months to 1 year. This means that for someone weighing 150 lbs (68 kg), they may gain approximately 1.5 to 2.4 lbs (0.7 to 1.1 kg). Nonetheless, it is worth mentioning that short-term use of the medication among adults typically does not lead to significant weight gain.

Comparing Zoloft With Other Antidepressants

Each SSRI, including Prozac, Paxil, Celexa, and Lexapro, has its own potential for causing weight gain. The risk of gaining weight is typically more apparent when these antidepressants are used for extended periods or at higher doses.

antidepressants

To sum up, the likelihood of gaining weight while using Zoloft is not definite and differs depending on the individual. If you have apprehensions about possible weight gain while on Zoloft, it is recommended to talk to your healthcare provider. They can provide guidance on potential alternatives or methods to minimize this unwanted effect.  

Reyus Mammadli

Healthy Lifestyle Advisor

I empower individuals with practical knowledge and proven strategies for achieving optimal well-being. My approach is centered on proactive health management, disease prevention, and effective recovery, ensuring that people make informed choices for a healthier life.

With a strong focus on holistic wellness, I integrate nutrition, physical activity, and lifestyle modifications to enhance overall health and longevity. My expertise stems from a Bachelor’s Degree in Medical Equipment and Electronics, complemented by international training in first aid and survival skills.

Beyond consulting, I am also a published author, sharing insights on nutrition, fitness, chronic pain management, and disease prevention through various works. My mission is simple: to help individuals cultivate sustainable habits that promote long-term health and well-being.

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