A lot of people are worried that taking Zoloft, a common antidepressant, might cause them to gain weight. The chance of this happening really varies from person to person, but overall, research shows that about 11% of individuals who take antidepressants, including Zoloft, experience a weight gain of at least 5% in their first year of treatment.
The Relationship Between Zoloft and Weight Gain
There is not complete clarity on the connection between Zoloft and weight gain, but professionals theorize that Zoloft and other antidepressants could potentially cause weight gain by affecting the brain’s neurotransmitters serotonin and histamine, which control appetite. Additionally, some individuals may feel tired or lethargic while taking Zoloft, leading to a decrease in physical activity and, in turn, weight gain.
Duration of Zoloft Use | Weight Gain in lbs per year |
---|---|
6 months | 1.2 to 2.4 lbs |
1 year | 1.5 to 2.6 lbs |
Extent of Weight Gain
To clarify, Zoloft users have been found to experience a weight increase of 1% to 1.6% of their original body weight over a span of 6 months to 1 year. This means that for someone weighing 150 lbs (68 kg), they may gain approximately 1.5 to 2.4 lbs (0.7 to 1.1 kg). Nonetheless, it is worth mentioning that short-term use of the medication among adults typically does not lead to significant weight gain.
Comparing Zoloft With Other Antidepressants
Each SSRI, including Prozac, Paxil, Celexa, and Lexapro, has its own potential for causing weight gain. The risk of gaining weight is typically more apparent when these antidepressants are used for extended periods or at higher doses.

To sum up, the likelihood of gaining weight while using Zoloft is not definite and differs depending on the individual. If you have apprehensions about possible weight gain while on Zoloft, it is recommended to talk to your healthcare provider. They can provide guidance on potential alternatives or methods to minimize this unwanted effect.
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